Danuta Szczesna-Cordary Selected Research

Familial Hypertrophic Cardiomyopathy (Cardiomyopathy, Familial Hypertrophic)

12/2014	Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanics.
9/2014	Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.
6/2014	In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain.
9/2013	Diversity and similarity of motor function and cross-bridge kinetics in papillary muscles of transgenic mice carrying myosin regulatory light chain mutations D166V and R58Q.
8/2013	Discrete effects of A57G-myosin essential light chain mutation associated with familial hypertrophic cardiomyopathy.
4/2012	The effect of myosin RLC phosphorylation in normal and cardiomyopathic mouse hearts.
2/2012	Myosin regulatory light chain mutation found in hypertrophic cardiomyopathy patients increases isometric force production in transgenic mice.
1/2012	Single molecule detection approach to muscle study: kinetics of a single cross-bridge during contraction of muscle.
12/2011	Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction.
10/2010	Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry.

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Danuta Szczesna-Cordary Research Topics

Disease

18	Familial Hypertrophic Cardiomyopathy (Cardiomyopathy, Familial Hypertrophic) 12/2014 - 01/2004
14	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2021 - 02/2012
10	Cardiomyopathies (Cardiomyopathy) 01/2022 - 01/2009
7	Hypertrophy 12/2015 - 01/2004
4	Heart Diseases (Heart Disease) 01/2021 - 07/2015
4	Cardiomegaly (Heart Hypertrophy) 01/2021 - 02/2012
3	Ischemia 07/2012 - 07/2005
2	Muscular Diseases (Myopathy) 12/2020 - 01/2019
2	Restrictive Cardiomyopathy 01/2019 - 08/2017
2	Cardiac Sudden Death (Sudden Cardiac Arrest) 08/2006 - 01/2004
1	Disease Progression 01/2021
1	Stroke (Strokes) 12/2020
1	Neoplasms (Cancer) 11/2020
1	Uterine Neoplasms (Uterine Cancer) 11/2020
1	Muscle Weakness 01/2019
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2018
1	Death (Near-Death Experience) 01/2016
1	familial dilated cardiomyopathy 06/2015
1	Myocardial Ischemia (Ischemic Heart Diseases) 07/2012
1	Lymphoma (Lymphomas) 06/2011
1	Asphyxia (Suffocation) 12/2010
1	Fatigue 04/2010
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 08/2006
1	Reperfusion Injury 07/2005

Drug/Important Bio-Agent (IBA)

23	Myosin Light Chains (Myosin Essential Light Chain)IBA 01/2021 - 07/2005
17	Myosins (Myosin)IBA 01/2022 - 08/2005
13	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2004
12	Ventricular MyosinsIBA 01/2021 - 08/2005
10	Cardiac MyosinsIBA 01/2021 - 01/2004
4	Alanine (L-Alanine)FDA Link 12/2015 - 12/2011
3	Valine (L-Valine)FDA Link 06/2014 - 03/2009
3	Aspartic Acid (Aspartate)FDA Link 06/2014 - 03/2009
3	Matrix Metalloproteinase 2 (Gelatinase A)IBA 07/2012 - 07/2005
2	CalciumIBA 01/2021 - 08/2005
2	Protein Isoforms (Isoforms)IBA 12/2020 - 01/2004
2	Adenosine Triphosphate (ATP)IBA 12/2020 - 01/2016
2	ActomyosinIBA 11/2020 - 04/2010
2	Arginine (L-Arginine)FDA Link 01/2019 - 01/2015
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 08/2013 - 12/2011
2	Contractile ProteinsIBA 07/2012 - 05/2011
1	MYK-461IBA 01/2021
1	Pharmaceutical PreparationsIBA 01/2021
1	Actins (F Actin)IBA 11/2020
1	Biomarkers (Surrogate Marker)IBA 11/2020
1	Glutamine (L-Glutamine)FDA Link 01/2019
1	RNA (Ribonucleic Acid)IBA 01/2019
1	Polymethyl Methacrylate (Sol)IBA 01/2019
1	sarcalumeninIBA 12/2015
1	Carrier Proteins (Binding Protein)IBA 12/2015
1	Fatty Acids (Saturated Fatty Acids)IBA 12/2015
1	Myosin-Light-Chain KinaseIBA 07/2015
1	Threonine (L-Threonine)FDA Link 01/2015
1	Cysteine (L-Cysteine)FDA Link 01/2015
1	Troponin IIBA 01/2015
1	IronIBA 05/2011
1	NitratesIBA 05/2011
1	NitritesIBA 05/2011
1	PhenanthrolinesIBA 05/2011
1	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2011
1	3-nitrotyrosineIBA 05/2011
1	Peroxynitrous Acid (Peroxynitrite)IBA 05/2011
1	myosin light chain 2IBA 12/2010
1	Lysine (L-Lysine)FDA Link 12/2007
1	Glutamic Acid (Glutamate)FDA Link 12/2007
1	Amino Acids FDA Link 12/2007
1	Troponin T (Troponin T1)IBA 11/2005
1	Trinitrotoluene (TNT)IBA 11/2005
1	Adenosine Triphosphatases (ATPase)IBA 08/2005
1	Hematoxylin (Haematoxylon)IBA 08/2005
1	Eosine Yellowish-(YS) (Eosin)IBA 08/2005

Therapy/Procedure

2	Therapeutics 01/2021 - 11/2020
1	RNAi Therapeutics 01/2019